SH3 and PX domain-containing protein 2B (IPR030512)

Short name: SH3PXD2B

Overlapping homologous superfamilies


Family relationships



SH3 and PX domain-containing protein 2B (SH3PXD2B, also known as Fad49 or Tks4) is an adaptor protein required for functional podosome formation [PMID: 19144821]. It binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides [PMID: 19755710]. It regulates epidermal growth factor-dependent cell migration [PMID: 22829589] and has been linked to cancer [PMID: 22260678]. Mutations in the SH3PXD2B gene cause Frank-ter Haar syndrome, a rare disease characterised by abnormalities that affect bone, heart, and eye development [PMID: 20137777]. It contains an N-terminal Phox homology (PX) domain and four SH3 domains.

GO terms

Biological Process

GO:0060348 bone development
GO:0001654 eye development
GO:0007507 heart development
GO:0071800 podosome assembly

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.