DNA (cytosine-5)-methyltransferase 3-like (IPR030486)

Short name: DNMT3L

Overlapping homologous superfamilies


Family relationships



DNA (cytosine-5)-methyltransferase 3-like (DNMT3L) is an enzymatically inactive regulatory factor of de novo DNA methyltransferases DNMT3A and DNMT3AB [PMID: 15105426, PMID: 15671018, PMID: 15861382]. It is related in sequence to DNMT3A and DNMT3B, but lacks cytosine methyltransferase activity due to the absence of catalytic residues. It recognises histone H3 tails that are unmethylated at lysine 4 and induces de novo DNA methylation by recruitment or activation of DNMT3A2 [PMID: 17687327]. It interacts with transcription factors to target DNMT3L/DNMT3B to specific DNA sequences [PMID: 24952347]. In mouse embryonic stem cells, DNMT3L functions as a negative regulator of methylation at promoters of bivalent genes whereas favours DNA methylation at gene bodies of housekeeping genes [PMID: 24074865].

GO terms

Biological Process

GO:0006306 DNA methylation

Molecular Function

GO:0019899 enzyme binding
GO:0030234 enzyme regulator activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.