Interleukin-6/GCSF/MGF (IPR030474)

Short name: IL-6/GCSF/MGF

Overlapping homologous superfamilies

Family relationships


Interleukin-6 (IL6), also refered to as B-cell stimulatory factor-2 (BSF-2) and interferon beta-2, is a cytokine involved in a wide variety of biological functions [PMID: 3491322]. It plays an essential role in the final differentiation of B-cells into IG-secreting cells, as well as inducing myeloma/plasmacytoma growth, nerve cell differentiation and, in hepatocytes, acute phase reactants [PMID: 3491322, PMID: 2037043].

A number of other cytokines may be grouped with IL6 on the basis of sequence similarity [PMID: 3491322, PMID: 2037043, PMID: 2472117]: these include granulocyte colony-stimulating factor (GCSF) and myelomonocytic growth factor (MGF). GCSF acts in hematopoiesis by affecting the production, differentiation and function of 2 related white cell groups in the blood [PMID: 2472117]. MGF also acts in hematopoiesis, stimulating proliferation and colony formation of normal and transformed avian cells of the myeloid lineage.

GO terms

Biological Process

GO:0006955 immune response

Molecular Function

GO:0005125 cytokine activity

Cellular Component

GO:0005576 extracellular region

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.