Conserved Site

ELO family, conserved site (IPR030457)

Short name: ELO_CS

Description

This entry represents a conserved site found in the ELO (Elongation of fatty acids protein) family members, such as:

  • Mammalian proteins ELOVL1 (Elongation of very long chain fatty acids protein 1) to ELOVL4 [PMID: 10791983]. These proteins all seem to be involved in the synthesis of very long chain fatty acids.
  • Yeast ELO1, ELO2 and ELO3 [PMID: 9211877]. They seem to be components of membrane-bound fatty acid elongation systems.
  • Caenorhabditis elegans hypothetical protein C40H1.4.
  • Caenorhabditis elegans hypothetical protein D2024.3.

The proteins have from 271 to 435 amino acid residues. Structurally, they seem to be formed of three sections: a N-terminal region with two transmembrane domains, a central hydrophilic loop and a C-terminal region that contains from one to three transmembrane domains. This entry represents a conserved region that contains three histidines. This region is located in the hydrophilic loop.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns