AT-rich interactive domain-containing protein 5B (IPR030408)

Short name: ARID5B

Overlapping homologous superfamilies


Family relationships



ARID5B, also known as modulator recognition factor-2 (Mrf-2), is a member of the AT-rich interaction domain (ARID) family of transcription factors [PMID: 22971728]. Human ARID5B forms complex with PHF2, a jmjC demethylase; this complex serves as a signal-sensing modulator of histone methylation and gene transcription [PMID: 21532585]. It facilitates chondrogenesis by recruiting the histone demethylase PHF2 to Sox9-regulated genes [PMID: 24276541]. Mouse Mrf-2 is required for adipogenesis and to maintain normal functions in mature adipocytes [PMID: 19913508].

The genetic variations in the ARID5B gene have been linked to susceptibility to type 2 diabetes [PMID: 22971728], acute lymphoblastic leukemia [PMID: 25310577] and coronary atherosclerosis [PMID: 18612189].

GO terms

Biological Process

GO:0060612 adipose tissue development
GO:0051091 positive regulation of DNA-binding transcription factor activity

Molecular Function

GO:0003713 transcription coactivator activity

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.