Conserved Site

RNA methyltransferase TrmA, conserved site (IPR030391)

Short name: MeTrfase_TrmA_CS


In Escherichia coli, the trmA protein is a tRNA (uracil-5-)-methyltransferase (EC: that catalyses the S-adenosylmethionine dependent methylation of U54 in all tRNAs. Orthologues of trmA are found in many eubacterial species. A number of uncharacterised homologues of trmA have been found [PMID: 8871555]:

  • Escherichia coli hypothetical protein ygcA and HI0333, the corresponding Haemophilus influenzae protein.
  • Haemophilus influenzae hypothetical protein HI0958.
  • Chlamydia trachomatis protein HOM1.
  • Fission yeast hypothetical protein SpAC4G8.07c.

It is probable that ygcA/HI0333 and HI0958 are responsible for the methylation of U747 and U1939 in 23S rRNA. In trmA, a cysteine is known to participate in the catalytic mechanism by forming a covalent adduct to C6 of uracil.

This entry represents a conserved site located at the C-terminal end. It contains a conserved histidine.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns