Pathways & interactions
ATP-binding cassette subfamily B member 10-like (IPR030260)
Short name: ABCB10-like
Overlapping homologous superfamilies
- Type I protein exporter (IPR039421)
- ATP-binding cassette subfamily B member 10-like (IPR030260)
This entry represents ATP-binding cassette subfamily B member 10 (ABCB10), which are eukaryotic proteins belonging to the ABC-B subfamily of the ABC transporter family. ABCB10 (also known as ABC mitochondrial erythroid, ABC-me, mABC2, or ABCBA) is found in the inner membrane of mitochondria. In humans, it is essential for erythropoiesis and for protection of mitochondria against oxidative stress [PMID: 10835348]. It is also expressed in many nonerythroid tissues, and hence may play roles not related to hemoglobin synthesis [PMID: 10922475]. The structure of ABCB10 has been solved [PMID: 23716676].
The ABC transporter family is a group of membrane proteins that use the hydrolysis of ATP to power the translocation of a wide variety of substrates across cellular membranes. ABC transporters minimally consist of two conserved regions: a highly conserved nucleotide-binding domain (NBD) and a less conserved transmembrane domain (TMD). Eukaryotic ABC proteins are usually organised either as full transporters (containing two NBDs and two TMDs), or as half transporters (containing one NBD and one TMD), that have to form homo- or heterodimers in order to constitute a functional protein [PMID: 11441126].
- PTHR24221:SF446 (PTHR24221:SF446)