Multidrug resistance protein 1 (IPR030258)

Short name: MDR1

Overlapping homologous superfamilies


Family relationships


The ABC transporter family is a group of membrane proteins that use the hydrolysis of ATP to power the translocation of a wide variety of substrates across cellular membranes. ABC transporters minimally consist of two conserved regions: a highly conserved nucleotide-binding domain (NBD) and a less conserved transmembrane domain (TMD). Eukaryotic ABC proteins are usually organised either as full transporters (containing two NBDs and two TMDs), or as half transporters (containing one NBD and one TMD), that have to form homo- or heterodimers in order to constitute a functional protein [PMID: 11441126].

Multidrug resistance protein 1 (MDR1, ABCB1, also known as P-glycoprotein, P-gp) is a eukaryotic protein belonging to the ABC-B subfamily of the ABC transporter family. MDR1 has broad substrate specificity, which includes substrates such as anticancer drugs, linear and cyclic peptides, and inhibitors of HIV protease [PMID: 16178819]. Overexpression of MDR1 can mediate the efflux of cytotoxic drugs out of cancer cells, leading to multidrug resistance [PMID: 25172788].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.