ATP-binding cassette subfamily B member 9 (IPR030254)

Short name: ABCB9

Overlapping homologous superfamilies

Family relationships


ATP-binding cassette subfamily B member 9 (ABCB9, also known as TAP-like and TAPL) is a eukaryotic member of the ABC transporter family. It translocates peptides from the cytosol into the lumen of lysosomes [PMID: 15863492]. It forms a homodimer and functions as a low affinity transporter that displays a broad peptide length specificity for 6-mer up to at least 59-mer peptides, with an optimum of 23-mers [PMID: 15863492].

The ABC transporter family is a group of membrane proteins that use the hydrolysis of ATP to power the translocation of a wide variety of substrates across cellular membranes. ABC transporters minimally consist of two conserved regions: a highly conserved nucleotide-binding domain (NBD) and a less conserved transmembrane domain (TMD). Eukaryotic ABC proteins are usually organised either as full transporters (containing two NBDs and two TMDs), or as half transporters (containing one NBD and one TMD), that have to form homo- or heterodimers in order to constitute a functional protein [PMID: 11441126].

GO terms

Biological Process

GO:0015833 peptide transport

Molecular Function

GO:0005524 ATP binding
GO:0015440 ATPase-coupled peptide transmembrane transporter activity

Cellular Component

GO:0016021 integral component of membrane
GO:0005765 lysosomal membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.