Transthyretin (IPR030178)

Short name: Transthyretin

Overlapping homologous superfamilies

Family relationships


Transthyretin (TTR) is a thyroid hormone-binding protein present in the plasma and/or cerebrospinal fluid of vertebrates. Transthyretin is a multifunctional protein. It distributes thyroid hormones in blood and indirectly transports vitamin A via binding to retinol-binding protein (RBP) [PMID: 8222576, PMID: 2209607, PMID: 9260907]. It also has proteolytic activity [PMID: 15033978, PMID: 20503435]. For instance, TTR can cleave apoA-I, the major HDL apolipoprotein [PMID: 20503435].

Transthyretin exists mainly as a homotetramer, with each subunit largely arranged into a beta-sheet structure. Transthyretin is implicated in human amyloid diseases [PMID: 24422526, PMID: 23225005].

GO terms

Biological Process

GO:0042572 retinol metabolic process
GO:0070327 thyroid hormone transport

Molecular Function

GO:0070324 thyroid hormone binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.