Family

I-BAR domain containing protein Pinkbar (IPR030126)

Short name: Pinkbar

Overlapping homologous superfamilies

None.

Family relationships

Description

Pinkbar (also known as BAI1-Associated Protein 2-Like 2, BAIAP2L2) is an I-BAR (Bin/amphipysin/Rvs) domain containing protein. BAR domain forms an anti-parallel all-helical dimer, with a curved (banana-like) shape, that promotes membrane tubulation. BAR domain proteins can be classified into three types: BAR, F-BAR and I-BAR. BAR and F-BAR proteins generate positive membrane curvature, while I-BAR proteins induce negative curvature [PMID: 21743456].

In humans Pinkbar (planar intestinal and kidney specific BAR domain protein) is specifically expressed in intestinal epithelial cells, where it localises to Rab13-positive vesicles and to the plasma membrane at intercellular junctions [PMID: 21743456]. The BAR domain of Pinkbar does not induce membrane protrusions or invaginations; instead, it promotes the formation of planar membrane sheets [PMID: 21743456].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER