Receptor-type tyrosine-protein kinase FLT3 (IPR030118)

Short name: FLT3

Overlapping homologous superfamilies


Family relationships



FLT3 is a class III receptor tyrosine kinase that plays an important role in hematopoietic differentiation. Mutations in FLT3 that lead to constitutive activation are among the most common molecular lesions found in acute myeloid leukemia (AML) [PMID: 17124058, PMID: 21262971]. FLT3 can be regulated by protein-tyrosine phosphatase DEP-1 [PMID: 21262971]. An adaptor protein, Grb10, has been shown to bind both normal and oncogenic FLT3 and induces PI3K-Akt and STAT5 signalling pathways resulting in an enhanced proliferation, survival and colony formation of hematopoietic cells [PMID: 23246379].

GO terms

Biological Process

GO:0030154 cell differentiation
GO:0030097 hemopoiesis

Molecular Function

GO:0004714 transmembrane receptor protein tyrosine kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.