Ornithine decarboxylase antizyme 2 (IPR029916)

Short name: ODC-AZ_2

Overlapping homologous superfamilies

Family relationships


Ornithine decarboxylase antizyme (ODC-AZ1 or ODC-Az-S) binds to, and destabilises, ornithine decarboxylase (ODC), a key enzyme in polyamine synthesis. A second antizyme (AZ2 or ODC-Az-L) exists in mammals and fish [PMID: 9782076, PMID: 10600644]. AZ1 and AZ2 are more conserved across species than they are within a single species, implying that AZ1 and AZ2 have maintained independent lineages since their divergence from a common ancestral gene [PMID: 10473601]. Both forms of antizyme can function as negative regulators of polyamine production and transport. In vitro, they both bind and inhibit ODC, however, only AZ1 can accelerate ODC degradation [PMID: 10600644].

GO terms

Biological Process

GO:0043086 negative regulation of catalytic activity
GO:0006595 polyamine metabolic process

Molecular Function

GO:0008073 ornithine decarboxylase inhibitor activity

Cellular Component

GO:0005829 cytosol

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.