cAMP-dependent transcription factor ATF1 (IPR029825)

Short name: ATF1

Overlapping homologous superfamilies


Family relationships



ATF1, CREB, and CREM constitute a subfamily of the basic leucine zipper transcription factors, and they activate gene expression by binding as homo- or heterodimers to the cAMP response elements (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'). ATF1 (activating transcription factor 1) plays important roles in cell survival and proliferation [PMID: 20980392, PMID: 11865068]. It is required for the development of preimplantation embryos [PMID: 24962037].

GO terms

Biological Process

GO:0006357 regulation of transcription by RNA polymerase II

Molecular Function

GO:0003700 DNA-binding transcription factor activity
GO:0046982 protein heterodimerization activity
GO:0043565 sequence-specific DNA binding

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.