Fos-related antigen 2 (IPR029814)

Short name: Fra2

Overlapping homologous superfamilies


Family relationships


Transcription factor activator protein (AP)-1, comprising Jun (c-Jun, JunB, and JunD) and Fos (c-Fos, FosB, Fra1, and Fra2) family members, plays a central role in regulating gene transcription in various biological processes [PMID: 12424143]. Fos protein family members form stable heterodimers with Jun proteins and thereby enhance their DNAbinding activity [PMID: 23904356].

This entry reprsents fos-related antigen 2 (Fra2), which is implicated in TGFbeta signalling. Fra2 is a positive regulator of bone and matrix formation in mice and humans [PMID: 20837772]. Fra2 is a STAT5 (signal transducers and activators of transcription 5) target gene regulated by IL-2 in human CD4 T cells [PMID: 24587342]. It may also play an important role in the pathogenesis of systemic sclerosis, an autoimmune disease of unknown etiology that affects the skin and a variety of internal organs including the lungs, heart, and gastrointestinal tract [PMID: 20039427].

GO terms

Biological Process

GO:0006357 regulation of transcription by RNA polymerase II

Molecular Function

GO:0003677 DNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.