Structural maintenance of chromosomes protein 1A, metazoan (IPR029683)

Short name: SMC1A_metazoan

Overlapping homologous superfamilies


Family relationships


Structural maintenance of chromosomes protein 1A (SMC1A) is a homologue of the yeast Smc1 protein, which is a component of the cohesin complex required for sister chromatid cohesion [PMID: 11877377]. In human, it is part of the core cohesion complex composed of SMC1A, SMC3, RAD21 and STAG proteins [PMID: 22885700]. These proteins form a ring structure that encircles sister chromatids to mediate sister chromatid cohesion [PMID: 22885700]. SMC1A binds to SMC3 through its hinge domain [PMID: 23106691]. Besides sister chromatid cohesion function, SMC1A-SMC3 heterodimer can also found in the RC-1 complex, a mammalian protein complex that promotes repair of DNA gaps and deletions through recombination [PMID: 23106691, PMID: 8392064]. This entry also includes Smc1 homologue from Caenorhabditis elegans, SMCL-1. Unlike canonical SMC proteins, SMCL-1 lacks hinge and coil domains, and its ATPase domain lacks conserved amino acids required for ATP hydrolysis [PMID: 28301465].

Mutations in SMC1A gene cause Cornelia de Lange syndrome 2 (CDLS2), which is a form of Cornelia de Lange syndrome, a clinically heterogeneous developmental disorder associated with malformations affecting multiple systems [PMID: 24756084, PMID: 18996922].

GO terms

Biological Process

GO:0006281 DNA repair
GO:0007064 mitotic sister chromatid cohesion

Molecular Function

GO:0003682 chromatin binding

Cellular Component

GO:0008278 cohesin complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.