O-GlcNAc transferase, C-terminal (IPR029489)

Short name: OGT/SEC/SPY_C

Overlapping homologous superfamilies


Domain relationships



This entry represents the C-terminal domain of the O-linked beta-N-acetylglucosamine transferase (OGT, also known as UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase), which catalyses the transfer of a single GlcNAc to the Ser or Thr of nucleocytoplasmic proteins [PMID: 18948359]. OGTs have two known domains: the N-terminal tetratricopeptide repeat domain and the C-terminal glycosyltransferase domain [PMID: 18536723]. Deletions of the C-terminal domain result in a complete loss of the enzyme activity [PMID: 10753899].

In animals, OGT is an essential protein that modifies transcription factors, nuclear pore proteins, kinases, and many other proteins. Abnormalities in OGT activities have been associated with type 2 diabetes [PMID: 18288188].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.