Domain

MMS22-like, C-terminal (IPR029424)

Short name: MMS22L_C

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

This entry represents the C-terminal of the MMS22L (Methyl methanesulfonate-sensitivity protein 22-like) protein.

MMS22L is a component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks [PMID: 21055983]. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double-strand breaks [PMID: 21055984, PMID: 21055985]. It may act by mediating the assembly of RAD51 filaments on ssDNA [PMID: 21055985].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam