Homologous Superfamily

Inosine triphosphate pyrophosphatase-like (IPR029001)

Short name: ITPase-like_fam

Overlapping entries


This entry represents the inosine triphosphate pyrophosphatase (ITPase)-like proteins. Members in this family include NTPases, such as Ham1-like protein (non-canonical purine NTP pyrophosphatase) and non-canonical purine NTP phosphatase (YjjX-like), Maf-like proteins and PRRC1.

Non-canonical purine NTP phosphatases are prokaryotic phosphatases that hydrolyse non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives [PMID: 16216582].

Ham1 is a pyrophosphatase that hydrolyses the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and 5-bromodeoxyuridine 5'-triphosphate (BrdUTP) to their respective monophosphate derivatives [PMID: 22531138].

Maf proteins exhibit nucleotide pyrophosphatase activity against canonical and modified nucleotides [PMID: 24210219]. Proline-rich and coiled-coil-containing protein 1 (PRRC1) is a Golgi-associated protein of unknown function [PMID: 15541471].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.