WHIM2 domain (IPR028941)

Short name: WHIM2_dom

Overlapping homologous superfamilies


Domain relationships



This entry represents the WHIM2 domain found in diverse eukaryotic chromatin proteins, such as animal BAZ/WAL and BPTF proteins, plant RLT and MBD9, and yeast Itc1. This domain contains the D-TOX E motif (also known as the Williams-Beuren syndrome DDT (WSD) motif) that is conserved from yeasts to animals [PMID: 22186017, PMID: 21525927, PMID: 19734295].

WHIM2 domain is a conserved alpha helical motif that along with the WHIM1 and WHIM3 motifs, and the DDT domain comprise an alpha helical module found in diverse eukaryotic chromatin proteins [PMID: 22186017]. Based on the Ioc3 structure, this module is inferred to interact with nucleosomal linker DNA and the SLIDE domain of ISWI proteins [PMID: 22186017, PMID: 21525927]. The resulting complex forms a protein ruler that measures out the spacing between two adjacent nucleosomes [PMID: 21525927]. The acidic residue from the GxD signature of WHIM2 is a major determinant of the interaction between the ISWI and WHIM motifs. The N-terminal portion of the WHIM2 motif also contacts the inter-nucleosomal linker DNA. The module shows a great domain architectural diversity and is often combined with other modified histone peptide recognizing and DNA binding domains, some of which discriminate methylated DNA [PMID: 22186017].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.