Domain

SAICAR synthetase/ADE2, N-terminal (IPR028923)

Short name: SAICAR_synt/ADE2_N

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC:6.3.2.6) (SAICAR synthetase) catalyses the seventh step in the de novo purine biosynthetic pathway; the ATP-dependent conversion of 5'-phosphoribosyl-5-aminoimidazole-4-carboxylic acid and aspartic acid to SAICAR [PMID: 1574589].

This domain can be found in SAICAR synthetases as a monofunctional protein from the bacteria (purC), fungi (ADE1) and plants (Pur7). In animals, this domain can be found in the N-terminal domain of a multifunctional enzyme (ADE2) possessing both the SAICAR synthetase and the phosphoribosylaminoimidazole carboxylase (AIR carboxylase) activity.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
HAMAP