NADPH-dependent diflavin oxidoreductase 1 (IPR028879)

Short name: NDOR1

Overlapping homologous superfamilies

Family relationships

  • Flavodoxin-like (IPR001094)
    • NADPH-dependent diflavin oxidoreductase 1 (IPR028879)


NDOR1, also known as Tah18 in budding yeast, is a conserved NAPDH-dependent diflavin reductase from eukaryotes. It is a component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery and part of an electron transfer chain functioning in an early step of cytosolic Fe/S biogenesis. It transfers electrons from NADPH to the Fe/S cluster DRE2 in budding yeasts or CIAPIN1 in humans [PMID: 21902732, PMID: 23596212].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003958 NADPH-hemoprotein reductase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.