A-kinase anchor protein 13 (IPR028852)

Short name: AKAP13

Overlapping homologous superfamilies


Family relationships



A-kinase anchor protein 13 (AKAP13, also known as AKAP-Lbc) belongs to the AKAP family, which contains functionally related proteins involved in the targeting of the PKA holoenzyme towards specific physiological substrates [PMID: 16460837]. AKAP13 anchors cAMP-dependent protein kinase (PKA) and acts as a guanine nucleotide exchange factor (GEF) that activates the GTPase RhoA [PMID: 11546812]. The Rho-GEF activity of AKAP13 can be inhibited by protein 14-3-3 when it adopts an oligomeric conformation [PMID: 16460837]. AKAP13 has been shown to be essential for cardiac development in mice [PMID: 20139090].

GO terms

Biological Process

GO:0035023 regulation of Rho protein signal transduction

Molecular Function

GO:0004691 cAMP-dependent protein kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.