Recoverin family (IPR028846)

Short name: Recoverin

Overlapping homologous superfamilies

Family relationships


Recoverin is a Ca(2+) -binding protein that controls phosphorylation of the visual receptor rhodopsin by inhibiting rhodopsin kinase (GRK-1) in photoreceptor cells [PMID: 16444517, PMID: 8242744]. It serves as a cancer-retina antigen that is expressed in retina and tumour cells and evokes antibodies and/or T cells in patients with cancer [PMID: 16444517, PMID: 22740915].

A number of other proteins including visinin, hippocalcin, neurocalcin, S-modulin, visinin-like protein, frequenin, guanylyl cyclase-activating proteins GCAP-1 and GCAP-2 [PMID: 9865963] belong to this family. All of the family members are generally small N-myristoylated proteins containing four EF-hand calcium-binding consensus motifs.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005509 calcium ion binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.