Stathmin-3 (IPR028835)

Short name: Stathmin-3

Overlapping homologous superfamilies

Family relationships


Stathmin is a tubulin-binding protein involved in the control of MT assembly and dynamics [PMID: 17029844]. The related stathmin-like family members include super cervical ganglion protein 10 (SCG10), SCG10-like protein (SCLIP), and RB3 [PMID: 11278715].

SCG10-like protein (also known as stathmin-3 or Sclip) exhibits microtubule-destabilising activity, which is antagonised by Stat3, a member of the signal transducer and activator of transcription (STAT) family [PMID: 16401721]. It may have a role in regulating neuronal morphology and structural plasticity [PMID: 17135267, PMID: 22577147].

GO terms

Biological Process

GO:0031122 cytoplasmic microtubule organization
GO:0031175 neuron projection development

Molecular Function

GO:0015631 tubulin binding

Cellular Component

GO:0005737 cytoplasm

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.