Voltage gated sodium channel, alpha-10 subunit (IPR028809)
Short name: Na_channel_a10su
Overlapping homologous superfamilies
- Voltage gated sodium channel, alpha subunit (IPR001696)
- Voltage gated sodium channel, alpha-10 subunit (IPR028809)
Nine voltage-gated sodium channels (Navs) are expressed in complex patterns in mammalian nerve and muscle. These channels mediate the influx of Na+ ions in response to local depolarising stimuli. Nav channels are composed of a pore-forming alpha-subunit associated with one or more auxiliary beta-subunits. The pore-forming alpha subunit is sufficient for functional expression, but the localisation, kinetics and voltage dependence of channel gating are modified by the beta subunits [PMID: 10798388, PMID: 16382098].
Nav1.8 (sodium channel protein type 10 subunit alpha) is a tetrodotoxin-resistant sodium channel isoform that plays a role in neuropathic pain mechanism [PMID: 9839820, PMID: 8538791, PMID: 8626372, PMID: 12514212].
- PTHR10037:SF208 (PTHR10037:SF208)