Voltage gated sodium channel, alpha-10 subunit (IPR028809)

Short name: Na_channel_a10su

Overlapping homologous superfamilies


Family relationships


Nine voltage-gated sodium channels (Navs) are expressed in complex patterns in mammalian nerve and muscle. These channels mediate the influx of Na+ ions in response to local depolarising stimuli. Nav channels are composed of a pore-forming alpha-subunit associated with one or more auxiliary beta-subunits. The pore-forming alpha subunit is sufficient for functional expression, but the localisation, kinetics and voltage dependence of channel gating are modified by the beta subunits [PMID: 10798388, PMID: 16382098].

Nav1.8 (sodium channel protein type 10 subunit alpha) is a tetrodotoxin-resistant sodium channel isoform that plays a role in neuropathic pain mechanism [PMID: 9839820, PMID: 8538791, PMID: 8626372, PMID: 12514212].

GO terms

Biological Process

GO:0019233 sensory perception of pain
GO:0006814 sodium ion transport

Molecular Function

GO:0005248 voltage-gated sodium channel activity

Cellular Component

GO:0001518 voltage-gated sodium channel complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.