Synapsin-1 (IPR028713)

Short name: SYN1

Overlapping homologous superfamilies


Family relationships

  • Synapsin (IPR001359)
    • Synapsin-1 (IPR028713)


The synapsins are a family of neuron-specific phosphoproteins that coat synaptic vesicles and are involved in the binding between these vesicles and the cytoskeleton (including actin filaments). The family comprises 5 homologous proteins 1a, 1b, 2a, 2b and 3. Synapsins 1, 2, and 3 are encoded by 3 different genes. The a and b isoforms of synapsin 1 and 2 are splice variants of the primary transcripts [PMID: 10940454].

This entry represents synapsin-1 (SYN1). Synapsin I is mainly associated with regulation of neurotransmitter release from presynaptic neuron terminals [PMID: 2859595]. Mutations in SYN1 gene cause epilepsy X-linked, with variable learning disabilities and behavior disorders (XELBD) [PMID: 14985377].

GO terms

Biological Process

GO:0007269 neurotransmitter secretion

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.