Synaptotagmin-5 (IPR028689)

Short name: SYT5

Overlapping homologous superfamilies

Family relationships



Synaptotagmin-5 (SYT5) belongs to the synaptotagmin family, which is a group of membrane-trafficking proteins that contain two C-terminal C2 domains. Most of the synaptotagmins have a unique N-terminal domain that is involved in membrane anchoring or specific ligand binding.

SYT5 is involved in the Ca2+-dependent stimulation of insulin exocytosis [PMID: 15190121]. SYT5 is also known as synaptotagmin IX (SYT9) in rodents. In PC12 (phaeochromocytoma) cells, it regulates Ca2+-dependent secretion [PMID: 11751925].

GO terms

Biological Process

GO:0017158 regulation of calcium ion-dependent exocytosis

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.