GDP-L-fucose synthase/GDP-L-colitose synthase (IPR028614)

Short name: GDP_fucose/colitose_synth

Overlapping homologous superfamilies

Family relationships



GDP-L-fucose synthase is responsible for the last step of the major metabolic pathway resulting in GDP-L-fucose synthesis from GDP-D-mannose. It catalyses a combined epimerase and NADPH-dependent reductase reaction, converting GDP-4-keto-6-D-deoxymannose to GDP-L-fucose [PMID: 8910301]. Since several cell-surface antigens, including the leukocyte Lewis system and cell-surface antigens in pathogenic bacteria, depend on the availability of GDP-L-fucose for their expression, the enzyme is a potential target for therapy in pathological states depending on selectin-mediated cell-to-cell interactions [PMID: 11021971].

This entry also includes ColC from Yersinia pseudotuberculosis. ColC is a GDP-L-colitose synthase, which is a bifunctional enzyme catalysaing the C-5 epimerization of GDP-4-keto-3,6-dideoxy-D-mannose and the subsequent C-4 keto reduction of the resulting L-epimer to give GDP-L-colitose [PMID: 15610039].

GO terms

Biological Process

GO:0009226 nucleotide-sugar biosynthetic process

Molecular Function

GO:0016491 oxidoreductase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.