Family

Katanin p60 subunit A-like 1, chordates (IPR028594)

Short name: Katnal1_chordates

Overlapping homologous superfamilies

Family relationships

Description

This entry represents Katanin p60 subunit A-like 1 (Katnal1) from chordates. Katnal1 regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. It colocalizes with microtubules throughout the basal and adluminal compartments of Sertoli cells. It severs microtubules in an ATP-dependent manner, promoting rapid reorganisation of cellular microtubule arrays [PMID: 22654668].

GO terms

Biological Process

GO:0051013 microtubule severing

Molecular Function

GO:0008568 microtubule-severing ATPase activity

Cellular Component

GO:0005874 microtubule

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
HAMAP