1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (IPR028400)

Short name: PLC-beta1

Overlapping homologous superfamilies


Family relationships


Phosphoinositide-specific phospholipase C (PI-PLC), also known as 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase, plays a role in the inositol phospholipid signaling by hydrolysing phosphatidylinositol-4,5-bisphosphate to produce the second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). These cause the increase of intracellular calcium concentration and the activation of protein kinase C (PKC), respectively.

The PLC family in murine or human species is comprised of multiple subtypes. On the basis of their structure, they have been divided into five classes, beta (beta-1, 2, 3 and 4), gamma (gamma-1 and 2), delta (delta-1, 3 and 4), epsilon, zeta, and eta types [PMID: 15140260, PMID: 15702972].

PLC-beta-1 is the predominant PLC isoform in the brain. PLC-beta-1 knockout mice exhibit behavioral abnormalities as a result of disrupted cortical development and plasticity [PMID: 18493969]. PLC-beta-1 is involved in cell cycle control [PMID: 10913438, PMID: 19028838] and in development and fertility [PMID: 15474310, PMID: 11464583]. It has an important role in the control of mouse oocyte meiosis. PLC beta 1 is first exclusively localised to the nucleus and then migrates to the cytoplasm when the oocyte is fully grown; this chronology being crucial for the production of competent oocytes [PMID: 17725492].

GO terms

Biological Process

GO:0007420 brain development
GO:0051726 regulation of cell cycle
GO:0007165 signal transduction

Molecular Function

GO:0004435 phosphatidylinositol phospholipase C activity

Cellular Component

GO:0005737 cytoplasm
GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.