Retinoblastoma-like protein 2 (IPR028308)

Short name: RB2

Overlapping homologous superfamilies


Family relationships


Retinoblastoma-like protein 2 (RBL2, also known as RB2 or p130) is a key regulator of entry into cell division. It is a component of the DREAM complex, which represses cell cycle-dependent genes in quiescent cells and plays a role in the cell cycle-dependent activation of G2/M genes [PMID: 17531812, PMID: 17671431]. It regulates cellular senescence and may act as a tumor suppressor [PMID: 19668264, PMID: 15750587, PMID: 19276650].

GO terms

Biological Process

GO:0051302 regulation of cell division

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005667 transcription factor complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.