Family

EB3 (IPR027738)

Short name: EB3

Overlapping homologous superfamilies

None.

Family relationships

Description

Microtubule-assocaiated protein RP/EB family member 3 (EB3) belongs to the RP/EB family, which consists of MAPRE1 (EB1), MAPRE2 (RP1, also known as EB2) and MAPRE3 (EBF3, also known as EB3). EB3 promotes persistent microtubule growth by suppressing catastrophes [PMID: 19255245]. Unlike EB1 or EB2, EB3 also binds to the F-actin-binding protein drebrin and the E3 ubiquitin ligase SIAH-1 [PMID: 18806788]. EB3 is specifically upregulated upon myogenic differentiation. Knockdown of EB3, but not that of EB1, prevents myoblast elongation and fusion into myotubes [PMID: 17658256].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER