Heat shock factor protein 2 (IPR027712)

Short name: HSF2

Overlapping homologous superfamilies


Family relationships


Four heat shock factor proteins (HSFs) have been identified in vertebrates (HSF1-4) [PMID: 10547058]. HSF2 is localised to the cytoplasm during normal growth and moves to the nucleus upon activation [PMID: 8339932], where it specifically binds heat shock promoter elements (HSE) and activates transcription. HSF2 may not be directly involved in the stress response, but rather in cell differentiation and development [PMID: 20945531, PMID: 20945530]. HSF1 and HSF2 can form heterotrimers, which could be a mechanism regulating transcription [PMID: 19129477].

GO terms

Biological Process

GO:0006357 regulation of transcription by RNA polymerase II

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.