Inosine triphosphate pyrophosphatase (IPR027502)

Short name: ITPase

Overlapping homologous superfamilies

Family relationships


Inosine triphosphate pyrophosphatase hydrolyses the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. It probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions [PMID: 17090528]. In yeast, it also hydrolyses 5-bromodeoxyuridine 5'-triphosphate (BrdUTP) [PMID: 9918490, PMID: 17899088].

GO terms

Biological Process

GO:0009143 nucleoside triphosphate catabolic process

Molecular Function

GO:0047429 nucleoside-triphosphate diphosphatase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.