Homologous Superfamily

Proteinase inhibitor I35b (TIMP), C-terminal (IPR027465)

Short name: TIMP_C

Overlapping entries


The tissue inhibitors of metalloproteinases (TIMPs) are endogenous inhibitors of the matrix metalloproteinases (MMPs). TIMPs have two domains, a larger N-terminal domain that carries the MMP-inhibitory activity, and a smaller C-domain that mediates other interactions, notably non-inhibitory interactions of TIMP-1 with pro-MMP-9 and of TIMP-2 with pro-MMP-2 [PMID: 10708863, PMID: 17660250, PMID: 22427646].

This superfamily represents the C-terminal domain.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.