Protein kinase C, delta (IPR027436)

Short name: PKC_delta

Overlapping homologous superfamilies


Family relationships


Protein kinase C, delta type is a member of the novel protein kinase C (nPKC) family. PKC delta plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis [PMID: 15774464], but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death [PMID: 18092819]. PKC delta is also involves in tumor suppression [PMID: 11877440], required for oxygen radical production by NADPH oxidase [PMID: 1748588, PMID: 18025218] and acts as positive or negative regulator in platelet functional responses [PMID: 16940418, PMID: 19587372].

PKC is a family of serine- and threonine-specific protein kinases that depend on lipids for activity. They can be activated by calcium but have a requirement for the second messenger diacylglycerol [PMID: 199594, PMID: 7358670]. Members of this family play key regulatory roles in various cellular processes. Currently, there are ten isoforms of PKC which can be classified into classical (alpha, beta I, beta II, gamma), novel (delta, epsilon, eta, theta) and atypical (zeta, iota/lambda) types based on their primary structure and biochemical characteristics [PMID: 9601053, PMID: 17661083, PMID: 9792904]. All PKCs contain a C-terminal kinase domain and an N-terminal regulatory domain.

The N-terminal regulatory domain of nPKC consists of a C2 domain follows by a double C1 domain (C1A and C1B). The C2 domain does not respond to calcium which makes nPKC diacylglycerol-sensitive but calcium-independent [PMID: 19033211, PMID: 1411571, PMID: 12359062].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004697 protein kinase C activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.