Diacylglycerol O-acyltransferase 1 (IPR027251)

Short name: Diacylglycerol_acylTrfase1

Overlapping homologous superfamilies


Family relationships


Diacylglycerol O-acyltransferase 1 (DGAT1) catalyses the final step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In plants, diacylglycerol O-acyltransferase 1 (DGAT1, TAG1) is a major enzyme for oil accumulation in seeds. It has complementary functions with PDAT1 acyltransferase that are essential for triacylglycerol synthesis and normal development of both seeds and pollen [PMID: 20040537, PMID: 10580283, PMID: 10601854, PMID: 12114588, PMID: 20101470].

In mammals, DGAT1 is a multifunctional acyltransferase capable of synthesizing diacylglycerol, retinyl, and wax esters in addition to triacylglycerol [PMID: 16106050]. In liver, it plays a role in esterifying exogenous fatty acids to glycerol [PMID: 22493088]. It also functions as the major acyl-CoA retinol acyltransferase in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders [PMID: 19028692].

GO terms

Biological Process

GO:0019432 triglyceride biosynthetic process

Molecular Function

GO:0004144 diacylglycerol O-acyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.