Semaphorin (IPR027231)

Short name: Semaphorin

Overlapping homologous superfamilies

Family relationships


Semaphorins are a family of cell surface and soluble proteins originally identified as axon guidance factors, but are now recognised to to be involved in a wide range of functions, including neural connectivity, angiogenesis, immunoregulation, and cancer [PMID: 16584533, PMID: 22897846, PMID: 22157652, PMID: 22895477]. Some semaphorins have an important role in the immune response, some regulate immune cell activation or differentiation, while others regulate the trafficking of immune cells [PMID: 22325954]. Semaphorins signal through two major receptor families, plexins and neuropilins (Nrps). All semaphorins have a Sema domain, characterised by a seven-blade beta propeller structure, which contains sites for semaphorin dimerisation and receptor binding.

Semaphorins are grouped into eight classes based on their structural domains, with classes 3-7 comprising the vertebrate semaphorins [PMID: 22157652].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0030215 semaphorin receptor binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.