Interleukin-36 beta (IPR027172)

Short name: IL-36_beta

Overlapping homologous superfamilies

Family relationships


Interleukin-36 cytokines constitute a novel cluster of cytokines with structural and functional similarities to IL-1 [PMID: 23029241]. Previously designated as interleukin-1 family members 5 - 10 (IL-1F5 to IL-1F10), they have recently been reclassified according to an updated cytokine nomenclature scheme [PMID: 20959797]. Family members include:

  • interleukin-36 alpha, beta and gamma (previously IL-1F6, IL-1F8 and IL-1F9, respectively), which are pro-inflammatory and signal through IL-1Rrp2 and IL-1RAcP [PMID: 14734551].
  • interleukin-36 receptor antagonist (previously IL-1F5), which binds IL-1Rrp2, acting as an antagonist for interleukins signalling via this route [PMID: 17908936].
  • interleukin-37 (IL-1F7), which exerts anti-inflammatory actions by suppressing production of pro-inflammatory cytokines [PMID: 20935647].
  • IL-1F10, whose function is unknown.

This entry represents interleukin-36 beta.

GO terms

Biological Process

GO:0006955 immune response
GO:0006954 inflammatory response

Molecular Function

GO:0005125 cytokine activity
GO:0005149 interleukin-1 receptor binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.