Nuclear cap-binding protein subunit 2 (IPR027157)

Short name: NCBP2

Overlapping homologous superfamilies

Family relationships



Nuclear cap-binding protein subunit 2 (NCBP2, also known as CBC2 and CBP20) forms the CBC complex with the nuclear cap-binding protein subunit 1 (IPR027159). The CBC complex binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in maturation, export and degradation of nuclear mRNAs [PMID: 8858145, PMID: 7651522, PMID: 11551508, PMID: 19632183]. In humans, the CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus and plays a central role in nonsense-mediated mRNA decay (NMD) [PMID: 17363367]. During cell proliferation, the CBC complex is involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2, thereby being required for miRNA-mediated RNA interference [PMID: 19632182].

GO terms

Biological Process

GO:0045292 mRNA cis splicing, via spliceosome

Molecular Function

GO:0000339 RNA cap binding

Cellular Component

GO:0005846 nuclear cap binding complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.