Neuropilin-1 (IPR027146)

Short name: NRP1

Overlapping homologous superfamilies

Family relationships


Neuropilins are essential multifunctional vertebrate cell surface receptors [PMID: 23116416]. They function as receptors for axon guidance factor semaphorin class 3 (Sema3), vascular endothelial growth factor (VEGF) and placenta growth factor-2 (PLGF-2).

Neuropilin-1 is involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, the PLGF-2 isoform of PLGF (placental growth factor), the VEGF-165 isoform of VEGF (vascular endothelial growth factor) and VEGF-B [PMID: 20133938, PMID: 9288753, PMID: 9529250, PMID: 10688880].

GO terms

Biological Process

GO:0001525 angiogenesis
GO:0009887 animal organ morphogenesis
GO:0007411 axon guidance
GO:0035767 endothelial cell chemotaxis
GO:0071526 semaphorin-plexin signaling pathway
GO:0048010 vascular endothelial growth factor receptor signaling pathway

Molecular Function

GO:0019838 growth factor binding
GO:0017154 semaphorin receptor activity
GO:0005021 vascular endothelial growth factor-activated receptor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.