Pathways & interactions
Tuberin/Ral GTPase-activating protein subunit alpha (IPR027107)
Short name: Tuberin/Ral-act_asu
Overlapping homologous superfamilies
- Tuberin/Ral GTPase-activating protein subunit alpha (IPR027107)
- Tuberin (IPR003913)
The activity of GTPases is regulated by the opposing effects of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Tuberin (tuberous sclerosis 2 protein or Tsc2) is believed to be a tumor suppressor and is able to stimulate specific GTPases. It stimulates the intrinsic GTPase activity of the Ras-related protein Rap1A and Rab5 [PMID: 8806680, PMID: 9045618]. In complex with Tsc1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. It acts as a GTPase-activating protein (GAP) for the small GTPase RheB, a direct activator of the protein kinase activity of mTORC1 [PMID: 12271141, PMID: 15340059].
Ral GTPase-activating protein subunit alpha is the catalytic subunit of the heterodimeric RalGAP complex which acts as a GTPase activator for the Ras-like small GTPases RalA and RalB [PMID: 19520869]. RalGAP complexes share structural and catalytic similarities with the tuberous sclerosis tumor suppressor complex [PMID: 19520869].
This family also includes the uncharacterised protein C18B11.11 from yeast.
- PTHR10063 (PTHR10063)