Lon protease (IPR027065)

Short name: Lon_Prtase

Overlapping homologous superfamilies


Family relationships


Lon protease belongs to the S16 peptidase family and is an ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins, as well as certain short-lived regulatory proteins. It is required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress [PMID: 17216028]. In pathogenic bacteria, it is required for the expression of virulence genes that promote cell infection [PMID: 10672180].

Lon (La) protease was the first ATP-dependent protease to be purified from E. coli [PMID: 9425059, PMID: 3042779, PMID: 8294008, PMID: 8226758]. The enzyme is a homotetramer of 87kDa subunits, with one proteolytic and one ATP-binding site per monomer, making it structurally less complex than other known ATP-dependent proteases [PMID: 3042779]. Despite this relative structural simplicity, Lon recognises its substrates directly, without delegating the task of substrate recognition to other enzymes [PMID: 3042779].

GO terms

Biological Process

GO:0030163 protein catabolic process

Molecular Function

GO:0005524 ATP binding
GO:0004176 ATP-dependent peptidase activity
GO:0004252 serine-type endopeptidase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.