CAAX prenyl protease 1 (IPR027057)

Short name: CAXX_Prtase_1

Overlapping homologous superfamilies


Family relationships



Following prenylation, proteins are subject to prenyl-dependent modifications at their C-terminal end, which are required for their subcellular targeting. The three C-terminal residues of the CAAX box prenylation signaling motif are removed before methylation of the free carboxyl group of the prenyl cysteine moiety.

CAAX prenyl protease 1 (also known as Ste24p) removes the C-terminal three residues of CAAX [PMID: 12039957, PMID: 9700155]. It also acts to cleave the N-terminal extension of the farnesylated A-factor mating pheromone in Saccharomyces cerevisiae [PMID: 9700155, PMID: 9725832, PMID: 10692417].

GO terms

Biological Process

GO:0071586 CAAX-box protein processing

Molecular Function

GO:0008233 peptidase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.