Disintegrin and metalloproteinase domain-containing protein 10 (IPR027053)

Short name: ADAM_10

Overlapping homologous superfamilies

Family relationships



Disintegrin and metalloproteinase domain-containing protein 10 (also known as ADAM10 or Kuzbanian; MEROPS identifier M12.210) is an endopeptidase (EC: [PMID: 12475894]. In humans and mice, it cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. It is responsible for the proteolytic release of several other cell-surface proteins. It controls the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis [PMID: 9244301]. The Drosophila orthologue is classified separately in the MEROPS database as M12.211.

GO terms

Biological Process

GO:0007219 Notch signaling pathway
GO:0006509 membrane protein ectodomain proteolysis

Molecular Function

GO:0004222 metalloendopeptidase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.