Family

Pappalysin-2 (IPR026918)

Short name: PAPPA2

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

Pappalysin-2 is a zinc binding metalloproteinase which specifically cleaves insulin-like growth factor-binding protein 5 (IGFBP-5). It shows limited proteolysis toward IGFBP-3 [PMID: 11264294].

GO terms

Biological Process

GO:0006508 proteolysis

Molecular Function

GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER