Adenomatous polyposis coli (APC) family (IPR026818)

Short name: Apc_fam

Overlapping homologous superfamilies


Family relationships


Adenomatous polyposis coli (APC) is a tumor suppressor protein that induces the degradation of oncogenic beta-catenin and negatively regulates Wnt signalling [PMID: 19619488]. It has roles in regulating cell migration, DNA replication/repair, mitosis and apoptosis [PMID: 17881494, PMID: 22162224]. APC regulates cell-cell adhesion and cell migration through activating the APC-stimulated guanine nucleotide-exchange factor (GEF; Asef) [PMID: 10947987, PMID: 21788986]. It acts as a mediator of ERBB2-dependent stabilisation of microtubules at the cell cortex [PMID: 20937854]. It is required for the localisation of MACF1/ACF7 to the cell membrane and this localisation of MACF1/ACF7 is critical for its function in microtubule stabilisation [PMID: 20937854]. APC mutations are particularly prevalent in colorectal cancer [PMID: 1528264].

The adenomatous polyposis coli protein family also includes APC2 [PMID: 10021369, PMID: 11691822] and APC-related protein 1 [PMID: 10766743].

GO terms

Biological Process

GO:0030178 negative regulation of Wnt signaling pathway

Molecular Function

GO:0008013 beta-catenin binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.