AP complex subunit beta (IPR026739)

Short name: AP_beta

Overlapping homologous superfamilies

Family relationships


Adaptor protein (AP) complexes function in protein transport via transport vesicles in different membrane traffic pathways. AP complexes are involved in the formation of clathrin-coated vesicles (CCVs) by recruiting the scaffold protein, clathrin. AP complexes are also involved in the cargo selection by recognising the sorting signals in proteins. Several AP complexes have been identified: AP-2 mediates endocytosis from the plasma membrane, while AP-1, AP-3 and AP-4 play a role in the endosomal/lysosomal sorting pathways [PMID: 14745134, PMID: 15473838]. AP complexes are heterotetramers which consist of two large subunits, one medium subunit and one small subunit. One of the large subunits (alpha, gamma, delta and epsilon) mediates binding to the target membrane. The other large subunit (beta) recruits clathrin through the clathrin-binding sequence [PMID: 11687498].

This entry represents the AP complexes beta subunit.

GO terms

Biological Process

GO:0016192 vesicle-mediated transport

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.