E3 ubiquitin-protein ligase RNF31 (IPR026254)

Short name: RNF31

Overlapping homologous superfamilies


Family relationships



RNF31 is a component of the linear ubiquitin chain assembly complex (LUBAC) [PMID: 17006537, PMID: 20005846, PMID: 19136968]. RNF31 is also known as HOIL-1L interacting protein (HOIP). It has been shown that RNF31 interacts with the muscle-specific kinase (MuSK) in mice [PMID: 14678832].

LUBAC catalyses the formation of linear ubiquitin chains and regulates immune and apoptopic signaling pathways [PMID: 21455173, PMID: 21455180, PMID: 21455181]. LUBAC consists of SHARPIN, HOIL-1 (also known as RBCK1) and HOIP [PMID: 17006537, PMID: 20956555].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004842 ubiquitin-protein transferase activity

Cellular Component

GO:0071797 LUBAC complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.